Cortical sensory aging is layer-specific
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1.
Hertie Institute for Clinical Brain Research
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2.
Otto-von-Guericke-Universität Magdeburg
Contributors
Contact person:
Description
We employed a unique approach and acquired layer-specific structural and functional magnetic resonance imaging (fMRI) data using 7T-MRI of the 2 (which was not certified by peer review) is the author/funder. All rights reserved. bioRxiv preprint doi: https://doi.org/10.1101/2023.12.01.567841; this version posted July 15, 2024. The subject of this preprint is the primary somatosensory cortex (SI) of healthy younger and older adults together with behavioral assessments. We also investigated an individual with unilateral congenital arm loss to test for the effect of reduced sensory input on the SI layer architecture.
Abstract (English)
The segregation of processes into cortical layers is a convergent feature in animal evolution. However, how changes in the cortical layer architecture interact with sensory system function and dysfunction remains unclear. We conducted functional and structural layer-specific in-vivo 7T-MRI of the primary somatosensory cortex in two cohorts of healthy younger and older adults. Input layer IV is enlarged and more myelinated in older adults, and associated with extended sensory input signals. Age-related cortical thinning is driven by deep layers and accompanied by increased myelination, but there is no clear evidence for reduced inhibition. Calcium imaging and histology in younger and older mice reveal increased sensory-evoked neuronal activity accompanied by increased parvalbumin expression as a potential inhibitory balance, with dynamic changes in layer-specific myelination across age groups. Using multimodal imaging, we demonstrate that middle and deep layers show specific sensitivity to aging across species.
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Additional details
Related works
- Is described by
- Data paper: 10.1101/2023.12.01.567841 (DOI)
Funding
Data quality
- Accuracy
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The source data were automatically extracted from each individual of the dataset (cohort 1 and cohort 2) using the following softwares: MIPAV, Freesurfer, MATLAB, SPM12, FSL, Python.
- Completeness
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The source data for all figures in the human analyses presented in the manuscript are provided.
- Conformity
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The human study was approved by the Ethics committee of the Otto-von-Guericke University Magdeburg. All mouse experiments were performed according to the NIH Guide for the Care and Use of Laboratory animals (2011) and the Directive of the European Communities Parliament and Council on the protection of animals used for scientific purposes (2010/63/EU) and were approved by the animal care committee of Sachsen-Anhalt, Germany.
- Consistency
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The source data is coherent with other data in the context of use.
- Credibility
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The source data were collected/extracted by Peng Liu, Juliane Doehler and Dr. Julia Henschke. In addtional, Elnaz Khosroshahi, Melina Trigoussis, Lilith-Sophie Lange, Anastasia Chrysidou, Johanna Nölle and Sophie Christine Busalt supported Ms. Liu and Ms. Doehler in participant recruitment and data collection, and Ridhim Joshi and Cathleen Knape supported Dr. Henschke for technical assistance and data collection in mice.
- Processability
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The source data are all in .csv format, and are available for statistical analyses.
- Relevance
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The source data are for the manuscript 'Cortical sensory aging is layer-specific', which is already published at BioRxiv as a preprint. https://doi.org/10.1101/2023.12.01.567841
- Timeliness
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The source data are for the manuscript 'Cortical sensory aging is layer-specific', which is already published at BioRxiv as a preprint. https://doi.org/10.1101/2023.12.01.567841
- Understandability
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The source data are for the manuscript 'Cortical sensory aging is layer-specific', which is already published at BioRxiv as a preprint. https://doi.org/10.1101/2023.12.01.567841